CAMK1G Protein (His-GST)
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北京 101111
Quick Overview for CAMK1G Protein (His-GST) (ABIN7317051)
抗原
See all CAMK1G 蛋白蛋白类型
宿主
资源
纯度
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标记
- This CAMK1G protein is labelled with His-GST.
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原理
- Recombinant Human CAMK1G/CaMKI gamma Protein (His & GST Tag)
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序列
- Met 1-Met 476
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产品特性
- A DNA sequence encoding the human CAMK1G isoform 1 (Q96NX5-1) (Met 1-Met 476) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G) (AA 1-476) protein (GST tag)
CAMK1G 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP, KAA
Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G) protein (Myc-DYKDDDDK Tag)CAMK1G 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied as sterile solution of 50 mM Tris, 100 mM NaCl, pH 8.0, 20 % glycerol, 0.3 mM DTT
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储存液
- Dithiothreitol (DTT)
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注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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有效期
- 6 months
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- CAMK1G (Calcium/calmodulin-Dependent Protein Kinase IG (CAMK1G))
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别名
- CAMK1G/CaMKI gamma
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背景
- CLICK3;CLICKIII;RP1-272L16.2;VWS1;dJ272L16.1,Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calcium binding proteins (calmodulin/CaM) and stimulates the activity of a variety of enzymes, including CaM kinases referred to as CaM-kinases (CaMKs), such as CaMKI, CaMKII, CaMKIV and CaMKK. Calmodulin-dependent protein kinase CL3/CaMKIγ is a memberane-anchored CaMK belonging to the CaM kinase family. Its C-terminal region is uniquely modified by two sequential lipidification steps: prenylation followed by a kinase-activity-regulated palmitoylation. These modifications are essential for CaMKIγ membrane anchoring and targeting into detergent-resistant lipid microdomains in the dendrites. It has been found that CaMKIγ critically contributed to BDNF-stimulated dendritic growth. Raft insertion of CaMKIγ specifically promoted dendritogenesis of cortical neurons by acting upstream of RacGEF STEF and Rac, both present in lipid rafts. Thus, CaMKIγ may represent a key element in the Ca2+-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons.
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分子量
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Calculated MW: 81.0 kDa
Observed MW: 75 kDa
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基因ID
- 57172
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UniProt
- Q96NX5
抗原
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