Cadherin 5 Protein (CDH5) (His tag)
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Quick Overview for Cadherin 5 Protein (CDH5) (His tag) (ABIN7320374)
抗原
See all Cadherin 5 (CDH5) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Cadherin 5 protein is labelled with His tag.
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原理
- Recombinant Mouse VE-Cadherin/CDH5 Protein (His Tag)
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序列
- Met 1-Ala 592
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产品特性
- A DNA sequence encoding the mouse CDH5 (NP_033998.2) extracellular domain (Met 1-Ala 592) was fused with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Cadherin 5 (CDH5) (AA 51-150) protein (GST tag)
CDH5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cadherin 5 (CDH5) (AA 29-599) protein (hIgG-His-tag)CDH5 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Cadherin 5 (CDH5)
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别名
- VE-Cadherin/CDH5
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背景
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Background: Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Synonym: 7B4,AA408225,Cd144,VE-Cad,Vec,VEcad,VECD
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分子量
- 63.5 (or 66) kDa
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NCBI登录号
- NP_033998
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途径
- Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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