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Quick Overview for ENPP7 Protein (His tag) (ABIN7194215)
抗原
See all ENPP7 蛋白蛋白类型
宿主
资源
纯度
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标记
- This ENPP7 protein is labelled with His tag.
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原理
- Recombinant Mouse ENPP7/NPP-7 Protein (His Tag)
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序列
- Met 1-Gln 421
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产品特性
- A DNA sequence encoding the mouse ENPP7 (Q3TIW9) (Met 1-Gln 421) was expressed, with a polyhistidine tag at the C-terminus.
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Alkaline Sphingomyelinase (Alk-Smase) (AA 1-458) protein (GST tag)
宿主: 人 宿主: 小麦胚 Recombinant WB, AA, AP, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 7.6
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- ENPP7 (Alkaline Sphingomyelinase (Alk-Smase))
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别名
- ENPP7/NPP-7
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背景
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Background: Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.
Synonym: Alk-SMase;Gm254
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分子量
- 47 kDa
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UniProt
- Q3TIW9
抗原
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