Adenylosuccinate Lyase Protein (ADSL) (His tag)
Quick Overview for Adenylosuccinate Lyase Protein (ADSL) (His tag) (ABIN7317594)
抗原
See all Adenylosuccinate Lyase (ADSL) 蛋白蛋白类型
宿主
资源
纯度
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标记
- This Adenylosuccinate Lyase protein is labelled with His tag.
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原理
- Recombinant Human ADSL/Adenylosuccinate Lyase Protein (His Tag)
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序列
- Met 1-Leu 484
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产品特性
- A DNA sequence encoding the human ADSL (P30566-1) (Met 1-Leu 484) was expressed, with a polyhistidine tag at the N-terminus.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please refer to the printed manual for detailed information.
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缓冲液
- Lyophilized from sterile PBS, 10 % glycerol, pH 7.5
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Adenylosuccinate Lyase (ADSL)
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别名
- ADSL/Adenylosuccinate Lyase
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背景
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Background: Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado). ADSL defect in different patients is often caused by different mutations to the enzyme.
Synonym: AMPS,ASASE,ASL
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分子量
- 57 kDa
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途径
- Ribonucleoside Biosynthetic Process
抗原
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