LRRC32&TGF-beta protein (His tag)
This Recombinant LRRC32&TGF-beta protein is expressed in HEK-293 Cells.
产品编号 ABIN7125972
发货至:
中国
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Quick Overview for LRRC32&TGF-beta protein (His tag) (ABIN7125972)
抗原
LRRC32&TGF-beta
蛋白类型
Recombinant
宿主
Cynomolgus
资源
HEK-293 Cells
纯度
>90 % as determined by SDS-PAGE.
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标记
- His tag
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原理
- Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free
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序列
- Ala 18 -Asn 627 (LRRC32) & Leu 30 - Ser 390 (TGF-beta 1)
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产品特性
- Cynomolgus LRRC32&TGF-beta 1 Heterotrimer Protein, His Tag&Tag Free is expressed from human 293 cells (HEK293). It contains AA Ala 18 -Asn 627 (LRRC32) & Leu 30 - Ser 390 (TGF-beta 1) (Accession # A0A2K5X2X9-1 (LRRC32) & A0A2K5TJB2-1 (TGF-beta 1).
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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应用备注
- Cynomolgus LRRC32&TGFB1 Heterotrimer protein, His Tag&Tag Free (the molar ratio of LRRC32 & 1 equals 1:2) is produced by co-expression of LRRC32 and 1, which has a calculated MW of 68.1 kDa (LRRC32), 28.5 (LAP) and 12.8 kDa (mature 1) respectively. LRRC32 is fused with a polyhistidine tag at the C-terminus and 1 contains no tag. The reducing (R) Heterotrimer protein migrates as 70 kDa (LRRC32), 37-43 kDa (LAP) and 13 kDa (mature 1) due to glycosylation respectively.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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储存方法
- -20°C
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- LRRC32&TGF-beta
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背景
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Synonyms: LRRC32 & TGF-beta 1,LRRC32&TGFB1,
GARP (LRRC32) is a transmembrane protein that binds latent-TGF-β1 and tethers it on the Treg surface. and has been proved to promote the activation and secretion of transforming growth factor β (TGF-β). The expression of GARP is highly on the surface activated Tregs and increases the suppressive function of Tregs. Additionally, GARP can bind to latent transforming growth factor β (TGF-β), thus promoting secretion and activation of TGF-β. TGF-β plays a critical rule for homeostasis and function of Tregs. Notably, it has been also observed that fibroblasts and endothelial cell lines that express GARP/latent TGF-β1 complexes do not activate TGF-β1. However, it cannot be excluded that specific stimuli are required to trigger TGF-β1 activation from complexes on the surface of these cell types. -
分子量
- 68.1 kDa (LRRC32) & 41.2 kDa (TGF-beta 1)
抗原
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