CD20 Protein-VLP
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- 抗原 See all CD20 (MS4A1) 蛋白
- CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))
- 蛋白类型
- VLP
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Human CD20 Full Length Protein-VLP (HEK293)
- 序列
- Met 1 - Pro 297
- 产品特性
- Human CD20 Full Length Protein-VLP (CDP-H52P6) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Pro 297 (Accession # P11836-1).
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product MS4A1 蛋白
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Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 141-188) protein (His-Avi Tag)
MS4A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 141-188) protein (His-Avi Tag,Biotin)MS4A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 1-297) (Active) protein-VLPMS4A1 宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC Imm, ELISA, Func, SPR Active
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 1-297) (Active) protein-VLP (Biotin)MS4A1 宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC Imm, ELISA, Func, SPR Active
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 1-297) protein (GST tag)MS4A1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) proteinMS4A1 宿主: 人 宿主: Mammalian Cells MSP Nanodisc
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) proteinMS4A1 宿主: 人 宿主: HEK-293 Cells Synthetic Nanodisc
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 1-297) (Active) protein (His tag)MS4A1 宿主: 人 宿主: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE. Active
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) (AA 141-188) protein (His-IF2DI Tag)MS4A1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1) protein (Fc Tag)MS4A1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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- 应用备注
- This protein carries no "tag". The protein has a calculated MW of 33.1 kDa.
- 说明
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Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display. - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -80 °C
- 储存方法
- -70°C
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- 抗原
- CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))
- 别名
- CD20 (MS4A1 产品)
- 背景
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Synonyms: MS4A1,CD20,MS4A-1,
Description: B-lymphocyte antigen CD20 is also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last, it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5), also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. - 分子量
- 33.1 kDa
- NCBI登录号
- NP_068769
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