MBP Protein (AA 99-330) (Fc Tag)
This Recombinant MBP protein is expressed in HEK-293 Cells.
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产品编号 ABIN7092845
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中国
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Quick Overview for MBP Protein (AA 99-330) (Fc Tag) (ABIN7092845)
抗原
MBP
蛋白类型
Recombinant
宿主
人
资源
HEK-293 Cells
应用范围
Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)
纯度
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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产品特性
- AA 99-330
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标记
- This MBP protein is labelled with Fc Tag.
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原理
- Recombinant human MBP Protein with N-terminal Human Fc tag
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特异性
- HFc(Glu99-Ala330) MBP(Met1-Arg304)
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产品特性
- Extracellular Domain Protein
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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应用备注
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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说明
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please see Certificate of Analysis for specific instructions of reconstitution.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- MBP
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背景
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Myelin A1 protein,Myelin membrane encephalitogenic protein
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008] -
分子量
- predicted molecular mass of 59.3 kDa after removal of the signal peptide. The apparent molecular mass of hFc-MBP is 70-100 kDa due to glycosylation.
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UniProt
- P02686
抗原
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