IL-31 Protein (AA 24-164) (His tag)
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Quick Overview for IL-31 Protein (AA 24-164) (His tag) (ABIN7013437)
抗原
See all IL-31 (IL31) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 24-164
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标记
- This IL-31 protein is labelled with His tag.
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产品特性
- Human IL-31 Protein, His Tag (MALS verified)
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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应用备注
- MALS verified
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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储存条件
- -20 °C
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- IL-31 (IL31) (Interleukin 31 (IL31))
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别名
- IL-31
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背景
- IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
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分子量
- 17.7 kDa
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NCBI登录号
- NP_001014358
抗原
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