SARS-CoV-2 NSP1 Protein (His tag)
This Recombinant SARS-CoV-2 NSP1 protein is expressed in 大肠杆菌（E. Coli）.
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产品编号 ABIN6952638
发货至:
中国
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Quick Overview for SARS-CoV-2 NSP1 Protein (His tag) (ABIN6952638)
抗原
SARS-CoV-2 NSP1
(SARS-CoV-2 Host Translation Inhibitor Nsp1 (SARS-CoV-2 NSP1))
蛋白类型
Recombinant
宿主
SARS Coronavirus-2 (SARS-CoV-2)
资源
大肠杆菌（E. Coli）
应用范围
SDS-PAGE (SDS)
纯度
>90 % as determined by SDS-PAGE.
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标记
- This SARS-CoV-2 NSP1 protein is labelled with His tag.
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原理
- SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag
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序列
- AA 1-180
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产品特性
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SARS-CoV-2 NSP1, His Tag is expressed from E.coli cells. It contains AA Met 1 - Gly 180 (Accession # YP_009725297.1). Predicted N-terminus: Met
This protein carries a polyhistidine tag at the C-terminus. -
过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, Arginine, pH 7.4
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
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For long term storage, the product should be stored at lyophilized state at -20°C or lower.
This product is stable after storage at:
4-8°C for 12 months in lyophilized state,
-70°C for 3 years under sterile conditions after reconstitution.
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- SARS-CoV-2 NSP1 (SARS-CoV-2 Host Translation Inhibitor Nsp1 (SARS-CoV-2 NSP1))
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别名
- SARS-CoV-2 Host Translation Inhibitor Nsp1
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物质类
- Viral Protein
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背景
- The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.
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分子量
- 21.7 kDa
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NCBI登录号
- YP_009725297
抗原
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