Human Adenovirus type 11 (HAdV-11) 蛋白
This Recombinant Human Adenovirus type 11 protein is expressed in HEK-293 Cells.
产品编号 ABIN6941930
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Beijing Economic Technological Development Area
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Quick Overview for Human Adenovirus type 11 (HAdV-11) 蛋白 (ABIN6941930)
抗原
Human Adenovirus type 11 (HAdV-11)
蛋白类型
Recombinant
宿主
Adenovirus
资源
HEK-293 Cells
纯度
0.99%
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原理
- Wild type Adenovirus type 11. Concentrated and purified virus particles from a double CsCl gradient purification with DNase treatment and dialysis. Safety category BSL2.
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产品特性
- Adenovirus Type 11 Particles, Wild-type
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纯化方法
- Human adenovirus type 11 particles (wild-type) produced in HEK293 cells and purified on CsCl gradient.
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说明
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This product is a concentrated source of highly-purified human Adenovirus type 11 particles (wild-type) from a lysate of optimally-infected 293 cells. Following double CsCl gradient purification with DNase treatment and dialysis, our Ad11 preparation is of very high quality, with minimal lot-to-lot variation.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, 50 mM Hepes pH 7.8, 7.5 % Sucrose
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储存条件
- -80 °C
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储存方法
- -80°C
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- Human Adenovirus type 11 (HAdV-11)
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别名
- Adenovirus Type 11
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物质类
- Virus
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背景
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Adenoviruses are medium-sized (80–100 nm), non-enveloped viruses. They have an icosahedral nucleocapsid containing a linear, double-stranded DNA genome of approximately 36 kb (Nermut, 1984). The viral genome is grouped into different transcriptional units, designated early (E1, E2, E3, E4), intermediate, and late. The E1 gene is essential for activation of other viral genes and for viral replication. Deletion of the E1 gene results in viruses that are replication incompetent in normal cells. However, replication-competent viral particles can be produced from E1-deleted viral vectors by providing the E1 gene in trans. The E3 gene is nonessential for either viral replication or infection (Flint, 1999).
Adenovirus type 11 (Ad11) is associated with respiratory tract infections and conjunctivitis. It belongs to the B group of adenoviruses (along with Ad3), which use a different host cell receptor to Ad5 (Ad5 belongs to group C). Ad11 uses CD46 (and other receptors), whereas Ad5 binds the Coxsackie and adenovirus receptor (CAR). CAR expression is often down-regulated in human tumors, making Ad5-mediated gene transfer problematic. This has resulted in the development of chimeric Ad5/Ad11 vectors for improved oncolytic gene therapy.
抗原
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