IL-13 Protein (AA 21-132) (Fc Tag)
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- 抗原 See all IL-13 (IL13) 蛋白
- IL-13 (IL13) (Interleukin 13 (IL13))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 21-132
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL-13 protein is labelled with Fc Tag.
- 纯度
- >90 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL13 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
- 储存条件
- -20 °C
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- 抗原
- IL-13 (IL13) (Interleukin 13 (IL13))
- 别名
- IL-13 (IL13 产品)
- 背景
- Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
- 分子量
- 38.8 kDa
- 途径
- JAK/STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
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