tau Protein (P301L, partial)
Quick Overview for tau Protein (P301L, partial) (ABIN6929400)
抗原
See all tau 蛋白蛋白类型
生物活性
宿主
资源
应用范围
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产品特性
- P301L, partial
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原理
- Active Human Recombinant Tau (K18), P301L mutant Protein Pre-formed Fibrils
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序列
- SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV LGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE
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特异性
- ~15.1 kDa
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纯化方法
- Ion-exchange Purified
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Biological Activity Comment
- Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
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tau Protein (full length), (P301S) (Active) protein
宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, WB, in vitro, in vivo Active
tau Protein (AA 241-380) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
tau Protein (AA 200-380) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
tau Protein (AA 1-412) protein (His tag)宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % by SDS - PAGE SDS
tau Protein (AA 2-752) protein (His tag)宿主: 大鼠 宿主: 酵母菌 Recombinant > 90 % SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- Lot specific
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缓冲液
- 10 mM HEPES, 100 mM NaCl pH 7.4
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储存条件
- -80 °C
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- tau (tau Protein)
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别名
- Tau
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背景
- Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
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UniProt
- P10636
抗原
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