PDGF-BB Homodimer (AA 82-190) (Active) 蛋白
This Recombinant protein is expressed in 大肠杆菌（E. Coli）.
Quick Overview for PDGF-BB Homodimer (AA 82-190) (Active) 蛋白 (ABIN6731333)
抗原
PDGF-BB Homodimer
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
>90 % as determined by reducing (R) and non-reducing (NR) SDS-PAGE.
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产品特性
- AA 82-190
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序列
- AA 82-190
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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PDGF-BB Homodimer (Active) protein (His tag)
宿主: 人 宿主: 酵母菌 Recombinant > 95 % as determined by reducing SDS-PAGE. Active
PDGF-BB Homodimer protein宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 98 % as determined by reducing SDS-PAGE.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.085 % TFA in 30 % ACN
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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- PDGF-BB Homodimer
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别名
- PDGF-BB
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背景
- PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.
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分子量
- 12.4 kDa
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NCBI登录号
- NP_002599
抗原
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