HpARI (AA 17-251) protein (His tag)
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北京 101111
Quick Overview for HpARI (AA 17-251) protein (His tag) (ABIN6253463)
抗原
蛋白类型
宿主
资源
纯度
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产品特性
- AA 17-251
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标记
- His tag
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原理
- HpARI (Alarmin Release Inhibitor) (rec.) (His)
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特异性
- Heligmosomoides polygyrus protein HpARI (aa 17-251) is fused at the C-terminus to a His-tag.
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交叉反应
- 人, 小鼠
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产品特性
- Heligmosomoides polygyrus protein HpARI (aa 17-251) is fused at the C-terminus to a His-tag.
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内毒素水平
- <0.01EU/μg purified protein (LAL test).
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- 1 mg/mL
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缓冲液
- Contains PBS.
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注意事项
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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储存条件
- 4 °C,-20 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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有效期
- 6 months
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- HpARI
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背景
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Heligmosomoides Polygyrus Alarmin Release Inhibitor
HpARI is a protein secreted by the mouse parasite Heligmosomoides polygyrus. The mature protein HpARI, containing three predicted Complement Control Protein (CCP)-like modules (also known as Short Consensus Repeats (SCRs) or sushi-domains), suppresses type 2 (allergic) immune responses through interference in the interleukin-33 (IL-33) pathway. During cell damage, HpARI gains access to the nucleus of necrotic cells, where it binds directly to IL-33 and nuclear DNA, preventing secretion and binding of IL-33 to its receptor. HpARI is a new type of reagent to prevent IL-33-mediated pathology.
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分子量
- ~40kDa (SDS-PAGE), ~40 kDa (Monomer) (SEC)
抗原
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