IL-2 Protein (AA 21-153)
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北京 101111
Quick Overview for IL-2 Protein (AA 21-153) (ABIN6253249)
抗原
See all IL-2 (IL2) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 21-153
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原理
- IL-2 (human) (rec.) (untagged)
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特异性
- The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met.
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产品特性
- Protein. The extracellular domain of human IL-2 (aa 21-153) with a N-terminal Met. Source: E. coli. Endotoxin content: <0.01EU/μg protein (LAL test, Lonza). Lyophilized from sterile 0.1 % TFA, 70 % acetonitrile. Purity: >95 % (SDS-PAGE). Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
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内毒素水平
- <0.01EU/μg protein (LAL test, Lonza).
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Biological Activity Comment
- Measured in a cell proliferation assay using CTLL2 cells. The ED50 for this effect is typically 0.35-1.4ng/ml.
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Interleukin 2 (IL2) (AA 21-153) protein
IL2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 2 (IL2) protein (His tag)IL2 宿主: 人 宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Interleukin 2 (IL2) (AA 21-169) protein (His-Avi Tag)IL2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 2 (IL2) (AA 21-169) protein (His-Avi Tag,Biotin)IL2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 2 (IL2) (AA 21-153) protein (mFc Tag)IL2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 2 (IL2) (Active) proteinIL2 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Interleukin 2 (IL2) (Active) proteinIL2 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Interleukin 2 (IL2) (AA 21-153) (Active) proteinIL2 宿主: 人 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 2 (IL2) (AA 21-153) protein (His tag)IL2 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 2 (IL2) (AA 21-153) (Active) protein (Fc Tag,AVI tag,Biotin)IL2 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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浓度
- Lot specific
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缓冲液
- Lyophilized from sterile 0.1 % TFA, 70 % acetonitrile.
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注意事项
- Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: -80°C
Use & Stability: Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- IL-2 (IL2) (Interleukin 2 (IL2))
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别名
- IL-2
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背景
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Alternate Names/Synonyms: Interleukin-2, Aldesleukin
Product Description: Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
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分子量
- ~14kDa (SDS-PAGE)
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NCBI登录号
- NP_000577
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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