Apoliprotein-J (ApoJ) / Clusterin 蛋白
This Native protein is expressed in Human.
Quick Overview for Apoliprotein-J (ApoJ) / Clusterin 蛋白 (ABIN621830)
抗原
Apoliprotein-J (ApoJ) / Clusterin
蛋白类型
Native
宿主
人
资源
Human
纯度
> 95 % as determined by SDS PAGE.
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产品特性
- Native Human Apoliprotein-J (ApoJ) / Clusterin
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Human native Clusterin was lyophilized from PBS, pH 7.5.Add deionized H2O to a working volume of 0.5 mg/ml and let the lyophilized pellet dissolve completely.
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储存条件
- -20 °C
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- Apoliprotein-J (ApoJ) / Clusterin
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背景
- Introduction: Clusterin also named Apoliprotein J (APO-J) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the a and b chains. These are assembled in anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil a-helices and three predicted amphipathic a-helices. Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition. A genuine function of clusterin has not been defined. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced insults caused by degraded and misfolded protein precipitates. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. Synonyms: CLI, AAG4, KUB1, SGP2, SGP-2, SP-40, TRPM2, MGC24903, Clusterin, Apolipoprotein J, Apo-J.
抗原
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