HCV E2 Protein (AA 482-671) (His tag)
This Recombinant HCV E2 protein is expressed in 大肠杆菌（E. Coli）.
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Quick Overview for HCV E2 Protein (AA 482-671) (His tag) (ABIN5853806)
抗原
See all HCV E2 蛋白
HCV E2
(Hepatitis C Virus Envelope Protein E2 (HCV E2))
蛋白类型
Recombinant
宿主
Hepatitis C Virus (HCV)
资源
大肠杆菌（E. Coli）
应用范围
SDS-PAGE (SDS)
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产品特性
- AA 482-671
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标记
- This HCV E2 protein is labelled with His tag.
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序列
- MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ
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纯化方法
- > 80% by SDS-PAGE
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Hepatitis C Virus Envelope Protein E2 (HCV E2) (AA 2634-2752) protein (His tag)
HCV E2 宿主: Hepatitis C Virus (HCV) 宿主: 大肠杆菌（E. Coli） Recombinant SDS
Hepatitis C Virus Envelope Protein E2 (HCV E2) protein (His tag)HCV E2 宿主: Hepatitis C Virus (HCV) 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.25 mg/mL
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储存方法
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
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别名
- HCV E2
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背景
- E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. Recombinant HCV (Hepatitis C Virus) E2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
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分子量
- 25.4 kDa (226aa)
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NCBI登录号
- NP_671491
抗原
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