Afadin Protein (MLLT4) (AA 1-141, Ras Binding Domain)
This Recombinant Afadin protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN5777013
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Afadin Protein (MLLT4) (AA 1-141, Ras Binding Domain) (ABIN5777013)
抗原
Afadin (MLLT4)
蛋白类型
Recombinant
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 90 % (SDS-PAGE)
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产品特性
- AA 1-141, Ras Binding Domain
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原理
- AF6-RBDGST (residues 1-141), GTP-H-Ras binding cytoplasmic protein, Afadin - Ras-binding domain, human, recombinant, E. coli
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Supplied in 25 mM HEPES pH 7.550 mM NaCl1 mM EDTA and 50 % glycerol
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储存液
- Without preservative
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注意事项
- Please centrifuge briefly before opening (volume ≤2 ml).,avoid freeze/thaw cycles
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储存条件
- -20 °C
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储存方法
- store at -20 °C avoid freeze/thaw cycles
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有效期
- 12 months
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- Afadin (MLLT4)
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别名
- AF6
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背景
- The amino terminus of Af6 was identified as the Rasbinding site. Additionally to the Ras-binding Af6 also binds Rap. ZO-1, a protein involved in the formation of tight junctions, also binds to Af6 close to the amino terminus thereby competing with Ras binding. These data suggest a participation of Af6 in the regulation of cell-cell contacts via a Ras-modulated interaction with ZO-1. In contrast to the well characterized effectors Raf, RalGEF, and PI(3)kinase, Af6 is a protein with no enzymatic function. It seems to serve as a scaffolding component for protein complexes. This would represent a new type of Ras effector because Ras binding in this case does not lead to the activation of the enzymatic activity of the effector.
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NCBI登录号
- NM_005936
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途径
- Cell-Cell Junction Organization
抗原
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