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VL2 (AA 1-462), (full length) protein (His-SUMO Tag)

宿主: Human Papillomavirus 18 (HPV-18) 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS
产品编号 ABIN5711008
发货至: 中国
  • 抗原
    VL2
    蛋白类型
    Recombinant
    产品特性
    full length, AA 1-462
    宿主
    • 1
    • 1
    Human Papillomavirus 18 (HPV-18)
    资源
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    His-SUMO Tag
    应用范围
    SDS-PAGE (SDS)
    序列
    MVSHRAARRK RASVTDLYKT CKQSGTCPPD VVPKVEGTTL ADKILQWSSL GIFLGGLGIG TGSGTGGRTG YIPLGGRSNT VVDVGPTRPP VVIEPVGPTD PSIVTLIEDS SVVTSGAPRP TFTGTSGFDI TSAGTTTPAV LDITPSSTSV SISTTNFTNP AFSDPSIIEV PQTGEVAGNV FVGTPTSGTH GYEEIPLQTF ASSGTGEEPI SSTPLPTVRR VAGPRLYSRA YQQVSVANPE FLTRPSSLIT YDNPAFEPVD TTLTFDPRSD VPDSDFMDII RLHRPALTSR RGTVRFSRLG QRATMFTRSG TQIGARVHFY HDISPIAPSP EYIELQPLVS ATEDNDLFDI YADDMDPAVP VPSRSTTSFA FFKYSPTISS ASSYSNVTVP LTSSWDVPVY TGPDITLPST TSVWPIVSPT APASTQYIGI HGTHYYLWPL YYFIPKKRKR VPYFFADGFV AA
    纯化方法
    SDS-PAGE
    纯度
    > 90 %
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  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.1-2 mg/mL
    缓冲液
    20 mM Tris-HCl based buffer, pH 8.0
    储存条件
    -80 °C,4 °C,-20 °C
    储存方法
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 抗原
    VL2
    物质类
    Viral Protein
    背景
    Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assbly, encapsidates the genome by direct interaction with the viral DNA .
    分子量
    65.6 kDa
    UniProt
    P06793
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