VL2 (AA 1-462), (full length) protein (His-SUMO Tag)
This Recombinant protein is expressed in 大肠杆菌（E. Coli）.
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Quick Overview for VL2 (AA 1-462), (full length) protein (His-SUMO Tag) (ABIN5711008)
抗原
VL2
蛋白类型
Recombinant
宿主
Human Papillomavirus 18 (HPV-18)
资源
大肠杆菌（E. Coli）
应用范围
SDS-PAGE (SDS)
纯度
> 90 %
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产品特性
- full length, AA 1-462
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标记
- His-SUMO Tag
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序列
- MVSHRAARRK RASVTDLYKT CKQSGTCPPD VVPKVEGTTL ADKILQWSSL GIFLGGLGIG TGSGTGGRTG YIPLGGRSNT VVDVGPTRPP VVIEPVGPTD PSIVTLIEDS SVVTSGAPRP TFTGTSGFDI TSAGTTTPAV LDITPSSTSV SISTTNFTNP AFSDPSIIEV PQTGEVAGNV FVGTPTSGTH GYEEIPLQTF ASSGTGEEPI SSTPLPTVRR VAGPRLYSRA YQQVSVANPE FLTRPSSLIT YDNPAFEPVD TTLTFDPRSD VPDSDFMDII RLHRPALTSR RGTVRFSRLG QRATMFTRSG TQIGARVHFY HDISPIAPSP EYIELQPLVS ATEDNDLFDI YADDMDPAVP VPSRSTTSFA FFKYSPTISS ASSYSNVTVP LTSSWDVPVY TGPDITLPST TSVWPIVSPT APASTQYIGI HGTHYYLWPL YYFIPKKRKR VPYFFADGFV AA
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纯化方法
- SDS-PAGE
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VL2 (AA 1-473), (full length) protein (His-SUMO Tag)
宿主: Human Papillomavirus 16 (HPV-16) 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
VL2 (AA 1-462), (full length) protein (His tag)宿主: Human Papillomavirus 18 (HPV-18) 宿主: 酵母菌 Recombinant > 90 % SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1-2 mg/mL
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缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
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储存条件
- -80 °C,4 °C,-20 °C
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储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- VL2
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物质类
- Viral Protein
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背景
- Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assbly, encapsidates the genome by direct interaction with the viral DNA .
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分子量
- 65.6 kDa
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UniProt
- P06793
抗原
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