ACVA Protein (AA 311-426)
(1 reference)Quick Overview for ACVA Protein (AA 311-426) (ABIN4369364)
抗原
See all ACVA 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 311-426
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品牌
- ActiveMax®
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序列
- AA 311-426
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产品特性
- This protein carries no "tag". The protein has a calculated MW of 13 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 0.1 EU per μg by the LAL method.
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Activin A (ACVA) (AA 311-426) protein
ACVA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Activin A (ACVA) (AA 309-424) protein (His tag)ACVA 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Activin A (ACVA) (AA 309-424) protein (His tag)ACVA 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.056 % TFA in 60 % ACN
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution
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: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." in: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).
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: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." in: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).
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- ACVA (Activin A (ACVA))
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别名
- Activin A /INHBA
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背景
- Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.
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分子量
- 13.0 kDa
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途径
- Hormone Transport, Peptide Hormone Metabolism
抗原
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