IgA1 蛋白
This Native IgA1 protein is expressed in Human.
产品编号 ABIN3119703
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for IgA1 蛋白 (ABIN3119703)
抗原
IgA1
蛋白类型
Native
宿主
人
资源
Human
纯度
> 95 %
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原理
- Immunoglobulin A1, Human Plasma (IgA1)
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产品特性
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Human plasma-derived IgA.
The predominant IgA subclass in circulation, comprising 90% of total serum IgA. It functions as a pathogen neutralizer, immune complex clearance facilitator, and cytoxicity mediator.
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应用备注
- For use in: IsoC
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 10 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.
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储存条件
- -80 °C
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储存方法
- -70°C or lower
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- IgA1
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别名
- Immunoglobulin A1
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背景
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Serum IgA1 is the predominant subclass of Immunoglobulin A in human circulation, comprising approximately 90% of total serum IgA. It eatures a distinctive hinge region with multiple O-linked glycans, distinguishing it structurally from IgA2. IgA1 serves critical immune functions by neutralizing pathogens, facilitating immune complex clearance, and mediating antibody-dependent cell-mediated cytotoxicity through FcαRI receptors on neutrophils and monocytes.
Aberrant glycosylation of IgA1 plays a central role in IgA nephropathy pathogenesis, where galactose-deficient IgA1 forms immune complexes that deposit in glomeruli, triggering kidney inflammation and damage. Additionally, IgA1 abnormalities are implicated in IgA vasculitis, celiac disease, and certain autoimmune conditions.
抗原
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