DKK3 Protein (AA 23-349) (His tag)
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- 抗原 See all DKK3 products
- DKK3
- 蛋白类型
- Recombinant
- 产品特性
- AA 23-349
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This DKK3 protein is labelled with His tag.
- 序列
- AA 23-349
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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DKK3 (AA 23-350) protein (His-Avi Tag)
宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
DKK3 (AA 23-350) protein (His-Avi Tag,Biotin)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
DKK3 (AA 1-350) protein (GST tag)宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
DKK3 (AA 22-350) protein (His tag)宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- DKK3
- 别名
- Dkk-3 (DKK3 产品)
- 背景
- Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
- 分子量
- 37.1 kDa
- NCBI登录号
- NP_056629
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