DKK3 Protein (AA 23-349) (His tag)
Quick Overview for DKK3 Protein (AA 23-349) (His tag) (ABIN2870735)
抗原
蛋白类型
宿主
资源
纯度
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产品特性
- AA 23-349
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标记
- This DKK3 protein is labelled with His tag.
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序列
- AA 23-349
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产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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DKK3 (AA 23-350) protein (His-Avi Tag)
宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
DKK3 (AA 23-350) protein (His-Avi Tag,Biotin)宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
DKK3 (AA 1-350) protein (GST tag)宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
DKK3 (AA 22-350) protein (His tag)宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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- DKK3
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别名
- Dkk-3
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背景
- Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
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分子量
- 37.1 kDa
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NCBI登录号
- NP_056629
抗原
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