Lipocalin 2 Protein (LCN2)
Quick Overview for Lipocalin 2 Protein (LCN2) (ABIN2830468)
抗原
See all Lipocalin 2 (LCN2) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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序列
- QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDG
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产品特性
- Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.5 ng/mL, corresponding to a specific activity of ＞ 2.0 x 106 IU/mg.
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过滤
- 0.2 μm filtered
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Lipocalin 2 (LCN2) (AA 21-198) protein (Fc Tag)
LCN2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-198) protein (His tag)LCN2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-198) protein (His tag)LCN2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-200) protein (Fc Tag)LCN2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) protein (His tag)LCN2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Lipocalin 2 (LCN2) (AA 1-198) protein (GST tag)LCN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 宿主: 大鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 20 mM PB, pH 7.4, 150 mM NaCl
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储存条件
- -20 °C
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- Lipocalin 2 (LCN2)
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别名
- LCN2
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背景
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Relevance: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. {ECO:0000269|PubMed:12453413}.
Synonyms: NGAL, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25 -
分子量
- 41.0 kDa
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UniProt
- P80188
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途径
- Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
抗原
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