Profilin Protein (PFN) (AA 1-163)
-
- 抗原 See all Profilin (PFN) 蛋白
- Profilin (PFN)
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-163
-
宿主
- 小鼠
-
资源
- 大肠杆菌（E. Coli）
- 应用范围
- SDS-PAGE (SDS)
- 原理
- Profilin (Toxoplasma gondii) (rec.)
- 交叉反应
- 小鼠
- 产品特性
- Recombinant profilin (Toxoplasma gondii) (aa 1-163).
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test).
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 100 μL sterile water.
- 浓度
- 0.1 mg/mL
- 缓冲液
- Contains PBS.
- 注意事项
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
- 储存条件
- 4 °C,-20 °C
- 储存方法
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- 有效期
- 6 months
-
- 抗原
- Profilin (PFN)
- 别名
- Profilin (PFN 产品)
- 背景
-
Inflammatory Profilin
TLR11, an innate sensor for profilin (Toxoplasma gondii), is an intracellular receptor that resides in the endoplasmic reticulum. The 12 membrane-spanning endoplasmic reticulum-resident protein UNC93B1 interacts directly with TLR11 and regulates the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12, a previously uncharacterized TLR, also recognizes profilin from Toxoplasma gondii. TLR12 is sufficient for recognition of profilin by plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both required in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice succumb rapidly to T. gondii infection.
- 分子量
- ~20kDa (SDS-PAGE)
- UniProt
- Q58NA1
-
