AADAT Protein (His tag)
Quick Overview for AADAT Protein (His tag) (ABIN2745733)
抗原
See all AADAT 蛋白蛋白类型
宿主
资源
应用范围
纯度
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标记
- This AADAT protein is labelled with His tag.
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原理
- Kynurenine Aminotransferase II (human) (rec.) (His)
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交叉反应
- 人
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产品特性
- Human full-length KAT II is fused at the N-terminus to a His-tag.
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Aminoadipate Aminotransferase (AADAT) (AA 1-429) protein (GST tag)
AADAT 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Aminoadipate Aminotransferase (AADAT) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)AADAT 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
Aminoadipate Aminotransferase (AADAT) (AA 30-425) protein (His-SUMO Tag)AADAT 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Aminoadipate Aminotransferase (AADAT) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)AADAT 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).
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注意事项
- After opening, prepare aliquots and store at -80 °C. Avoid freeze/thaw cycles.
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储存条件
- -20 °C,-80 °C
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储存方法
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Short Term Storage: -20°C
Long Term Storage: -80°C
Use & Stability: Stable for at least 6 months after receipt when stored at -80°C.
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有效期
- 6 months
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- AADAT (Aminoadipate Aminotransferase (AADAT))
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别名
- Kynurenine Aminotransferase II
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背景
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hKAT II, KAT2, alpha-Aminoadipate Aminotransferase (Mitochondrial), AADAT, EC 2.6.1.7
Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
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分子量
- ~49.8kDa
抗原
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