Shugoshin Protein (Myc-DYKDDDDK Tag)
Quick Overview for Shugoshin Protein (Myc-DYKDDDDK Tag) (ABIN2731936)
抗原
See all Shugoshin (SGOL1) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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标记
- This Shugoshin protein is labelled with Myc-DYKDDDDK Tag.
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产品特性
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- Recombinant human SGOL1 / SGO1 (transcript variant B1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Shugoshin 1 (SGOL1) (AA 1-561) protein (His tag)
custom-made SGOL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Shugoshin 1 (SGOL1) (AA 1-517) protein (His tag)custom-made SGOL1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Shugoshin 1 (SGOL1) (AA 1-292) protein (GST tag)SGOL1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
说明
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The tag is located at the C-terminal.
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限制
- 仅限研究用
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浓度
- 50 μg/mL
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缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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储存条件
- -80 °C
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储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
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别名
- Sgol1,sgo1
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背景
- The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
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分子量
- 31.1 kDa
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NCBI登录号
- NP_001012411
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途径
- Maintenance of Protein Location
抗原
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