PLEKHM2 Protein (Myc-DYKDDDDK Tag)
Quick Overview for PLEKHM2 Protein (Myc-DYKDDDDK Tag) (ABIN2729169)
抗原
See all PLEKHM2 蛋白蛋白类型
宿主
资源
应用范围
纯度
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标记
- This PLEKHM2 protein is labelled with Myc-DYKDDDDK Tag.
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产品特性
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- Recombinant human PLEKHM2 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 2 (PLEKHM2) (AA 1-1018) protein (His tag)
custom-made PLEKHM2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 2 (PLEKHM2) (AA 1-1019) protein (His tag)custom-made PLEKHM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 2 (PLEKHM2) (AA 1-440) protein (GST tag)PLEKHM2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
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应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
说明
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The tag is located at the C-terminal.
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限制
- 仅限研究用
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浓度
- 50 μg/mL
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缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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储存条件
- -80 °C
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储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- PLEKHM2 (Pleckstrin Homology Domain Containing, Family M (With RUN Domain) Member 2 (PLEKHM2))
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别名
- Plekhm2
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背景
- This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction.
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分子量
- 112.6 kDa
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NCBI登录号
- NP_055979
抗原
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