抗原 See all LOX 蛋白

LOX (Lysyl Oxidase (LOX))

蛋白类型

Recombinant

宿主 6 4 1 1 1 1

人

资源 7 4 2 1

HEK-293 Cells

标记

This LOX protein is labelled with Myc-DYKDDDDK Tag.

应用范围

Antibody Production (AbP), Standard (STD)

产品特性

Recombinant human Lysyl oxidase protein expressed in HEK293 cells.
Produced with end-sequenced ORF clone

纯度

> 80 % as determined by SDS-PAGE and Coomassie blue staining

Lysyl Oxidase (LOX) (AA 174-417) protein (His tag)

LOX 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Lysyl Oxidase (LOX) (AA 169-417) protein (His tag)

Crystallography grade LOX 宿主: 人宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

Lysyl Oxidase (LOX) (AA 163-411) protein (His tag)

Crystallography grade LOX 宿主: 小鼠宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys

Lysyl Oxidase (LOX) protein (His tag)

LOX 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant > 97 % SDS, WB, Imm, PC

Lysyl Oxidase (LOX) (AA 213-417) protein (His tag,GST tag)

LOX 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS, WB, Imm, PC

Lysyl Oxidase (LOX) (AA 169-417) protein (His tag)

LOX 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 80 % SDS, WB, Imm, PC

Lysyl Oxidase (LOX) (AA 207-411) protein (His tag,GST tag)

LOX 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS, WB, Imm, PC

Lysyl Oxidase (LOX) (AA 213-417) (Active) protein (His tag,GST tag)

LOX 宿主: 人宿主: 大肠杆菌（E. Coli） > 90 % AcA, CC Active

Lysyl Oxidase (LOX) protein

LOX 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant > 95 % SDS, WB, ELISA, IP

Lysyl Oxidase (LOX) protein (DYKDDDDK-His Tag)

LOX 宿主: 人宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

应用备注: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
说明: The tag is located at the C-terminal.
限制: 仅限研究用

浓度: 50 μg/mL
缓冲液: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
储存条件: -80 °C
储存方法: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Pilecki, Holm, Schlosser, Moeller, Wohl, Zuk, Heumüller, Wallis, Moestrup, Sengle, Holmskov, Sorensen: "Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation." in: The Journal of biological chemistry, Vol. 291, Issue 3, pp. 1103-14, (2016) (PubMed).

Kondala, Puri, Banka, Sachdeva, Sakhuja: "Short-term prognosis of potential celiac disease in Indian patients." in: United European gastroenterology journal, Vol. 4, Issue 2, pp. 275-80, (2016) (PubMed).

Cox, Rumney, Schoof, Perryman, Høye, Agrawal, Bird, Latif, Forrest, Evans, Huggins, Lang, Linding, Gartland, Erler: "The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase." in: Nature, Vol. 522, Issue 7554, pp. 106-10, (2015) (PubMed).

Miller, Morton, Pinese, Saturno, Jamieson, McGhee, Timpson, Leach, McGarry, Shanks, Bailey, Chang, Oien, Karim, Au, Steele, Carter, McKay, Anderson, Evans, Marais, Springer, Biankin, Erler, Sansom: "Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy." in: EMBO molecular medicine, Vol. 7, Issue 8, pp. 1063-76, (2015) (PubMed).

Richter, Dayaram, Gilmartin, Ganji, Pemmasani, Van Der Key, Shohet, Donehower, Kumar: "WIP1 phosphatase as a potential therapeutic target in neuroblastoma." in: PLoS ONE, Vol. 10, Issue 2, pp. e0115635, (2015) (PubMed).

Zhao, Sagare, Ma, Halliday, Kong, Kisler, Winkler, Ramanathan, Kanekiyo, Bu, Owens, Rege, Si, Ahuja, Zhu, Miller, Schneider, Maeda, Maeda, Sugawara, Ichida, Zlokovic: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).

Arnold, Kent, Hogarth, Schlatt, Prasad, Haenisch, Walsh, Muller, Griswold, Amory, Isoherranen: "Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations." in: Journal of lipid research, Vol. 56, Issue 2, pp. 342-57, (2015) (PubMed).

Wilson, Bradley, Shaw, Wagenmakers: "Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature." in: Histochemistry and cell biology, Vol. 142, Issue 3, pp. 245-56, (2014) (PubMed).

Nandhu, Hu, Cole, Erdreich-Epstein, Rodriguez-Gil, Viapiano: "Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas." in: Cancer research, Vol. 74, Issue 19, pp. 5435-48, (2014) (PubMed).

Divakaran, Hines, McCarver: "Human hepatic UGT2B15 developmental expression." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 141, Issue 1, pp. 292-9, (2014) (PubMed).

Tansley, Betteridge, Gunawardena, Jacques, Owens, Pilkington, Arnold, Yasin, Moraitis, Wedderburn, McHugh: "Anti-MDA5 autoantibodies in juvenile dermatomyositis identify a distinct clinical phenotype: a prospective cohort study." in: Arthritis research & therapy, Vol. 16, Issue 4, pp. R138, (2014) (PubMed).

Baker, Bird, Welti, Gourlaouen, Lang, Murray, Reynolds, Cox, Erler: "Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis." in: Cancer research, Vol. 73, Issue 2, pp. 583-94, (2013) (PubMed).

抗原: LOX (Lysyl Oxidase (LOX))
别名: Lysyl Oxidase (LOX 产品)
别名: LOX Protein, Xlox Protein, MGC146507 Protein, lox Protein, zgc:77447 Protein, AI893619 Protein, TSC-160 Protein, H-rev142 Protein, Rrg1 Protein, lysyl oxidase Protein, lysyl oxidase a Protein, lysyl oxidase L homeolog Protein, LOX Protein, lox Protein, loxa Protein, lox.L Protein, Lox Protein
背景: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. [UniProtKB/Swiss-Prot Function]
分子量: 46.8 kDa
NCBI登录号: NP_002308
途径: SARS-CoV-2 Protein Interactome

LOX Protein (Myc-DYKDDDDK Tag)

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