CEACAM1 蛋白
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Quick Overview for CEACAM1 蛋白 (ABIN2669353)
抗原
See all CEACAM1 蛋白蛋白类型
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纯度
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Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-428) (Active) protein (His tag)
CEACAM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 1-464) protein (GST tag)CEACAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 1-468) protein (GST tag)CEACAM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) protein (His tag)CEACAM1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) protein (His tag)CEACAM1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-428) protein (His tag)CEACAM1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) (AA 35-143) protein (His-IF2DI Tag)CEACAM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 20 mM Phosphate buffer pH 7.5, 0.5M sodium chloride, 1.5Mm EDTA, 10 % glycerol.
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储存条件
- -20 °C
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- CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1))
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别名
- CEACAM 1
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背景
- The carcinoembryonic antigen (CEA) family is composed of 29 genes tandemly arranged on chromosome 19q13.2. Based on nucleotide homologies, these genes are classified into 2 major subfamilies, the CEACAM and the pregnancy-specific glycoprotein (PSG) subgroups. The CEACAM-encoded proteins include CEA, CEACAM1, and other CEA gene members. CEACAM1 (Carcinoembryonic antigen related cell adhesion molecule 1, also BGP1, CD66a), is involved in the regulation of important biological processes, such asinsulin homeostasis , angiogenesis, and modulation of the immune response . Expression of CEACAM1 is associated with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small Cell Lung Carcinoma (NSCLC) bladder, prostate, thyroid, breast, colon and gastric carcinomas . In addition, CEACAM1 has also been identified as receptors for host-specific viruses and bacteria in mice and humans such as Neisseria, Haemophilus influenzae, Moraxella catarrhalis and mouse hepatitis virus (MHV) . The binding of Opa (the neisserial colony opacity associated) proteins occurs at the non-glycosylated face of the N-domain of CEACAM1 , heterophilic adhesion facilitates bacterial colonization of the gut and bacterial phagocytosis by neutrophilis, and is involved in the granulocytes migration during inflammatory responses. The N-terminal domain of CEACAM1 has been implicated also in mediating homophilic adhesion . This is an important factor for the embryonic organization of the intestinal epithelium and hepatocytes in the liver, in placental trophoblasts, during muscle and tooth development and vascularisation of the central nervous system, in angiogenesis and in the negative regulation of cell proliferation.
抗原
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