Nef 蛋白
宿主: Human Immunodeficiency Virus (HIV)
宿主: 大肠杆菌（E. Coli）
Recombinant
>90 %
EDA, HPLC, SDS
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- 抗原
- Nef
- 蛋白类型
- Recombinant
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宿主
- Human Immunodeficiency Virus (HIV)
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- Endotoxin Detection Assay (EDA), High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
- 纯度
- >90 %
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- The protein should be reconstituted in apirogenic sterile water or 1X PBS.
- 缓冲液
- 1 % glycerol
- 储存条件
- 4 °C
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- 抗原
- Nef
- 别名
- F-protein Protein, nef protein Protein, nef Protein
- 物质类
- Viral Protein
- 背景
- HIV-1 Nef is a 27 kDa protein abundantly produced shortly after virus infection. Nef is an essential factor for efficient viral replication and pathogenesis, it also facilitates virus replication and enhances virions infectivity. Nef exerts pleiotropic effects: down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK, protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Nef protein bypasses host T-cell signaling by inducing a trascriptional program nearly identical to that of anti-CD3 cell activation.
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