Thrombopoietin Protein (THPO) (AA 22-195)
Quick Overview for Thrombopoietin Protein (THPO) (AA 22-195) (ABIN2667585)
抗原
See all Thrombopoietin (THPO) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 22-195
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内毒素水平
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Less than 0.1 ng per μg of protein.
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Thrombopoietin (THPO) protein (His tag)
THPO 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Thrombopoietin (THPO) (AA 23-195) protein (His tag)THPO 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 22-195) protein (His-IF2DI Tag)THPO 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 1-349) protein (GST tag)THPO 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Thrombopoietin (THPO) (AA 22-356) (Active) proteinTHPO 宿主: 小鼠 宿主: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Thrombopoietin (THPO) proteinTHPO 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 97,00% SDS
Thrombopoietin (THPO) proteinTHPO 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 97,00% SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: The expected ED50 is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg, as determined by the dose-dependent stimulation of the proliferation of human MO7e cells.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-0.5 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
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缓冲液
- Lyophilized, carrier-free.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- Thrombopoietin (THPO)
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别名
- Thrombopoietin
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背景
- Mouse Thrombopoietin (TPO) is a protein consisting of an N-terminus domain with homology to erythropoietin (EPO) and a C-terminus domain with multiple N-linked and O-linked glycosylation sites. TPO is a key regulator of megakaryocytopoiesis and thrombopoiesis. It signals through the c-mpl receptor and stimulates the proliferation and maturation of megakaryocytes, hence, TPO plays an important role in regulating the level of circulating platelets in vivo. It has also been shown that TPO is able to promote the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitors. Besides its hematopoietic effects, TPO is expressed in the brain where it promotes apoptosis of hypoxia sensitized neurons and inhibits neuronal differentiation by blocking NGF induced signaling.
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分子量
- The 174 amino acid recombinant protein has a predicted molecular mass of 18.7 kDa. The predicted N-terminal amino acid is Ser.
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途径
- JAK/STAT Signaling, Hormone Activity
抗原
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