IL-9 Protein (AA 19-144)
Our Local Distributor
北京 101111
Quick Overview for IL-9 Protein (AA 19-144) (ABIN2667544)
抗原
See all IL-9 (IL9) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
-
-
产品特性
- AA 19-144
-
内毒素水平
-
Less than 0.1 ng per μg of protein.
-
-
Interleukin 9 (IL9) (AA 19-144) protein (His tag)
IL9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 9 (IL9) (AA 19-144) protein (Fc Tag)IL9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 9 (IL9) (AA 19-144) protein (Fc Tag)IL9 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 9 (IL9) (Active) proteinIL9 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >85 % as determined by SDS-PAGE Func Active
Interleukin 9 (IL9) (AA 19-144) protein (His-IF2DI Tag)IL9 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 9 (IL9) protein (His tag)IL9 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Interleukin 9 (IL9) (AA 1-144) protein (GST tag)IL9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Interleukin 9 (IL9) (AA 19-144) protein (His tag)IL9 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 85 % SDS
Interleukin 9 (IL9) (AA 19-144) protein (Fc Tag)IL9 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 9 (IL9) (AA 19-144) protein (His tag)IL9 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
Biological activity: ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5.0 x 106 units/mg as determined by the dose-dependent stimulation of the proliferation of human M07e cells.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
-
缓冲液
- Lyophilized
-
注意事项
- Avoid repeated freeze/thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- Unopened vial can be stored at -20°C or -70°C.
-
-
- IL-9 (IL9) (Interleukin 9 (IL9))
-
别名
- IL-9
-
背景
- IL-9 was initially identified in mice as a T cell growth factor. Human and murine IL-9 show a 56 % amino acid sequence homology. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation, and prevents apoptosis. The IL-9 receptor consists of the cytokine-specific IL-9 receptor α-chain (IL-9Rα ) and the common γ-chain that is shared by IL-2, IL-4, IL-7, IL-15, and IL-21. IL-9 is expressed by activated Th9, Th17, Tregs, and mast cells and appears to play an important role in the development and function of subsets within the CD4+ T cell lineage. IL-9 also inhibits immune responses by enhancing the suppressive properties of Tregs and by recruiting immunosuppressive mast cells to sites of inflammation. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a key factor in the pathogenesis of bronchial hyperresponsiveness. In this sense, it has been described that IL-9 and IL-9R expression are increased in lungs of asthmatic patients. In addition, IL-9 promotes mast cell mediated intestinal permeability and plays a role in the development of food allergies. IL-9 has also been associated with atopic dermatitis.
-
分子量
- The 127 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 14.2 kDa. The predicted N-terminal amino acid is Met.
-
途径
- JAK/STAT Signaling
抗原
-
