IL16 Protein (AA 10-130)
-
- 抗原 See all IL16 蛋白
- IL16 (Interleukin 16 (IL16))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 10-130
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 应用范围
- Flow Cytometry (FACS)
- 纯度
- >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
- 内毒素水平
-
Less than 0.1 ng per μg of protein.
- Top Product
- Discover our top product IL16 蛋白
-
Interleukin 16 (IL16) (AA 1203-1332) (Active) protein (His tag)
IL16 宿主: 人 宿主: 大肠杆菌（E. Coli） > 97 % CC, AcA Active
Interleukin 16 (IL16) (AA 1212-1332) protein (His-IF2DI Tag)IL16 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 16 (IL16) (AA 1-454) protein (GST tag)IL16 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
-
Biological activity: Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 50.0 - 1000.0 ng/ml.
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
- 缓冲液
- Lyophilized, carrier-free.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Unopened vial can be stored at -20°C or -70°C.
-
- 抗原
- IL16 (Interleukin 16 (IL16))
- 别名
- IL-16 (IL16 产品)
- 别名
- IL16 Protein, LCF Protein, NIL16 Protein, PRIL16 Protein, prIL-16 Protein, mKIAA4048 Protein, IL-16 Protein, interleukin 16 Protein, IL16 Protein, Il16 Protein
- 背景
- IL-16 is a proinflammatory cytokine synthesized as a 631-amino acid precursor protein (pro-IL-16). The pro-IL-16 is expressed at high level in T cells. After cell activation via the T cell rceptor, the C-terminal cytokine domain (121 amino acids) can be released from the N-terminal prodomain by caspase-3 and become biological active. Self-aggregation into homotetramer is required for its biological activities. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. IL-16 also induces the expression of CD25 and activates CD4+ T cells synergically with IL-2 or IL-15. IL-16 can also induce IL-1, IL-6 and TNF-α production in monocytes. It has been shown tha IL-16 can inhibit HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. The pro-IL-16 has been identified as a T lymphocyte cell cycle growth suppressor. In primary T cells, nuclear presence of pro-IL-16 results in a resting state. Pro-IL-16 can function as a scadffold protein which can interact with GA-binding protein β, HDAC3, and heat shock protein 70.
- 分子量
- The 121 amino acid recombinant protein has a predicted molecular mass of approximately 12.4 kDa. The predicted N-terminal amino acid is Ser.
-
