IL16 Protein (AA 10-130)
Quick Overview for IL16 Protein (AA 10-130) (ABIN2667464)
抗原
See all IL16 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 10-130
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内毒素水平
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Less than 0.1 ng per μg of protein.
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Interleukin 16 (IL16) (AA 1-1322) protein (His tag)
custom-made IL16 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Interleukin 16 (IL16) (AA 1-1332) protein (His tag)custom-made IL16 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Interleukin 16 (IL16) (AA 1203-1332) (Active) protein (His tag)IL16 宿主: 人 宿主: 大肠杆菌（E. Coli） > 97 % AcA, CC Active
Interleukin 16 (IL16) (AA 1-454) protein (GST tag)IL16 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 16 (IL16) (AA 502-631) proteinIL16 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90% by SDS-PAGE SDS
Interleukin 16 (IL16) proteinIL16 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Interleukin 16 (IL16) proteinIL16 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 16 (IL16) proteinIL16 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 16 (IL16) proteinIL16 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
Interleukin 16 (IL16) proteinIL16 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 50.0 - 1000.0 ng/ml.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.
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缓冲液
- Lyophilized, carrier-free.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- IL16 (Interleukin 16 (IL16))
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别名
- IL-16
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背景
- IL-16 is a proinflammatory cytokine synthesized as a 631-amino acid precursor protein (pro-IL-16). The pro-IL-16 is expressed at high level in T cells. After cell activation via the T cell rceptor, the C-terminal cytokine domain (121 amino acids) can be released from the N-terminal prodomain by caspase-3 and become biological active. Self-aggregation into homotetramer is required for its biological activities. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. IL-16 also induces the expression of CD25 and activates CD4+ T cells synergically with IL-2 or IL-15. IL-16 can also induce IL-1, IL-6 and TNF-α production in monocytes. It has been shown tha IL-16 can inhibit HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. The pro-IL-16 has been identified as a T lymphocyte cell cycle growth suppressor. In primary T cells, nuclear presence of pro-IL-16 results in a resting state. Pro-IL-16 can function as a scadffold protein which can interact with GA-binding protein β, HDAC3, and heat shock protein 70.
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分子量
- The 121 amino acid recombinant protein has a predicted molecular mass of approximately 12.4 kDa. The predicted N-terminal amino acid is Ser.
抗原
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