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CCL24 Protein (AA 27-119)

This Recombinant CCL24 protein is expressed in 大肠杆菌(E. Coli).
产品编号 ABIN2666899
发货至: 中国

Quick Overview for CCL24 Protein (AA 27-119) (ABIN2666899)

抗原

See all CCL24 蛋白
CCL24 (Chemokine (C-C Motif) Ligand 24 (CCL24))

蛋白类型

Recombinant

生物活性

Active

宿主

  • 10
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资源

  • 15
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大肠杆菌(E. Coli)

应用范围

Western Blotting (WB)

纯度

> 98 % , as determined by Coomassie stained SDS-PAGE.
  • 产品特性

    AA 27-119

    过滤

    0.22 μm filtered

    内毒素水平

    Less than 0.01 ng per μg cytokine as determined by the LAL method.

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  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Biological activity: Bioactivity was measured by its property to chemoattract BaF3-mCCR3 transfectants in a dose dependent manner.

    限制

    仅限研究用
  • 状态

    Liquid

    溶解方式

    For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.

    缓冲液

    0.22 μm filtered protein solution is in PBS.

    注意事项

    Avoid repeated freeze/thaw cycles.

    储存条件

    -20 °C

    储存方法

    Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
  • 抗原

    CCL24 (Chemokine (C-C Motif) Ligand 24 (CCL24))

    别名

    CCL24

    背景

    CLL24 was initially cloned from a library of activated macrophages, and using human eosinophils, it was shown that it binds to the receptor of eotaxin-1 (CCL11) and MCP-4 (CCL13). In addition, CCL24 shares the CCR3 receptor with CCL26, CCL5, and CCL7. Eotaxin/CCR3 expression has been studied extensively in the pathogenesis of asthma and allergy. In addition, the eotaxin/CCR3 axis has been associated to additional inflammatory and autoimmune disorders including inflammatory bowel disease, multiple sclerosis, eosinophilic esophagitis, and rheumatoid arthritis. CCL24 has also been associated to neovascular age related macular degeneration.

    分子量

    The 93 amino acid recombinant protein has a predicted molecular mass of approximately 10.4 kDa. The DTT-reduced protein migrates at approximately 12 kDa and non-reduced protein migrates at 14 kDa by SDS-PAGE. The N-terminal amino acid is Valine.

    途径

    Regulation of Actin Filament Polymerization
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