Lipocalin 2 Protein (LCN2) (AA 21-200, C-Term, His10)
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Quick Overview for Lipocalin 2 Protein (LCN2) (AA 21-200, C-Term, His10) (ABIN2666723)
抗原
See all Lipocalin 2 (LCN2) 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 21-200, His10, C-Term
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过滤
- 0.22 μm filtered
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内毒素水平
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Less than 0.01 ng per μg cytokine as determine by the LAL method.
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Lipocalin 2 (LCN2) (AA 21-198) protein (Fc Tag)
LCN2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-198) protein (His tag)LCN2 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) protein (His tag)LCN2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Lipocalin 2 (LCN2) protein (Fc Tag)LCN2 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Lipocalin 2 (LCN2) (AA 1-198) protein (GST tag)LCN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 宿主: 大鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: BC50 ≥ 0.7 μM, by dose dependent binding of the protein (4 μM) with [ Fe3+(DHBA)3] complex.
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- For maximum results, quick spin vial prior to opening.
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缓冲液
- 0.22 μm filtered protein solution is in PBS.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for three months, or at -70°C for six months.
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- Lipocalin 2 (LCN2)
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别名
- NGAL
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背景
- NGAL, also known as lipocalin 2, LCN2, and siderocalin, is a small molecule composed of 178 amino acids. It belongs to the lipocalin superfamily of 20 structurally related secreted proteins. Members of the lipocalin family share a highly conserved fold with an eight stranded antiparallel β barrel, and act as a transporter, carrying small molecules to specific cells. NGAL occurs predominantly in a monomeric form, with a small percentage occurring as a dimer or trimer. It is a critical component of innate immunity because its ability to bind iron-siderophore complexes limits bacterial growth. Mouse NGAL is detected in lung, spleen, uterus, vagina and epididymis. In addition to its role in innate immunity, it is a promising biomarker for acute kidney injury that is beginning to be used in clinical practice in addition to research studies.
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分子量
- The 195 amino acid recombinant protein has a predicted molecular mass of approximately 23 kDa. The DTT-reduced and non-reduced protein migrate at approximately 26-29 and 25-28 kDa by SDS-PAGE respectively. The N-terminal amino acid is blocked.
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途径
- Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
抗原
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