CCL21 Protein (AA 24-134)
Quick Overview for CCL21 Protein (AA 24-134) (ABIN2666610)
抗原
See all CCL21 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 24-134
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过滤
- 0.22 μm filtered
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内毒素水平
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Less than 0.01 ng per μg cytokine as determined by the LAL method.
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Chemokine (C-C Motif) Ligand 21 (CCL21) (Active) protein
CCL21 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Chemokine (C-C Motif) Ligand 21 (CCL21) (AA 24-133) protein (His tag)CCL21 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chemokine (C-C Motif) Ligand 21 (CCL21) (AA 1-134) protein (GST tag)CCL21 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: Bioactivity was measured by its property to chemoattract Baf3-hCCR7 transfectants in a dose dependent manner.
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- For maximum results, quick spin vial prior to opening. The protein can be aliquoted and stored from -20 °C to -70 °C. Stock solutions can also be prepared at 50-100 μg/mL in sterile buffer (PBS, HPBS, DPBS, or EBSS) containing carrier protein such as 0.2-1 % BSA or HSA and stored in working aliquots at -20 °C to -70 °C.
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缓冲液
- 0.22 μm filtered protein solution is in PBS.
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored between 2°C and 8°C for one month, at -20°C for six months, or at -70°C for one year.
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- CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))
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别名
- CCL21
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背景
- CCL21 is a CC chemokine highly expressed in lymph nodes. CCL21 is only 32 % identical to CCL19 at the amino acid level, nevertheless, these chemokines bind to the same receptor CCR7. CCL21 has a unique extension of about 30 amino acids with two extra cysteine residues in its carboxyl terminus. CCL21 is expressed in synovial tissue in rhematoid arthritis (RA), and it has been suggested that CCL21, but not CCL19, induces human microvascular endothelial cell (HMVEC) migration and/or tube formation. In addition, it has been reported that sustained high concentrations of either soluble or immobilized CCL19 and CCL21 inhibit T cell proliferation and IL-2 secretion.
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分子量
- The 111 amino acid recombinant protein has a predicted molecular mass of approximately 12 kDa. The DTT-reduced protein migrates at approximately 16 kDa and non-reduced protein at approximately 17 kDa by SDS-PAGE. The N-terminal amino acid is Ser.
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途径
- Regulation of Actin Filament Polymerization
抗原
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