BMP7 Protein (AA 315-431)
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北京 101111
Quick Overview for BMP7 Protein (AA 315-431) (ABIN2666467)
抗原
See all BMP7 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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产品特性
- AA 315-431
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内毒素水平
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Less than 0.1 ng per μg of protein.
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Bone Morphogenetic Protein 7 (BMP7) (AA 1-431) protein (GST tag)
BMP7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 7 (BMP7) (AA 292-430) (Active) protein (His tag)BMP7 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） > 97 % CC, AcA Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Biological activity: BMP-7 induces alkaline phosphatase production on ATDC-5 cells. The ED50 = 0.02 - 0.04 μg/ml, corresponding to a specific activity of 2.5 - 5.0 x 104 unit/mg.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.
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缓冲液
- Lyophilized
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- -20 °C
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储存方法
- Unopened vial can be stored at -20°C or -70°C.
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- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
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别名
- BMP-7
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背景
- Bone morphogenetic proteins (BMPs) belong to the transforming growth factor beta (TGF-β) superfamily. BMPs play a key role in embryonic development, especially during heart, neural and cartilage development. Around 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, and are composed of type I and II subtypes. Four type I receptors have been identified: type IA and IB BMP receptors, type IA activin receptor, and activin receptor-like kinase I. Three type II receptors have also been recognized: type II BMP receptor and type II and IIB activin receptors. BMP-7, originally identified by its properties to induce bone formation, has been identified as an anti-fibrotic molecule, antagonizing TGF-β1. Fibrosis is associated with the emergence of fibroblasts originating from endothelial cells, suggesting an endothelial-mesenchymal transition (EndMT). TGF-β1 induces endothelial cells to undergo EndMT, whereas bone BMP-7 preserved the endothelial phenotype. BMP-7 inhibits fibrosis in the kidney, lung, liver, heart, peritonium, oral submucosa tissue, and colonic wall.
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分子量
- The 117 amino acid recombinant protein has a predicted molecular mass of approximately 13 kDa. Recombinant human BMP-7 is a 28.8 kDa homodimeric glycoprotein. The predicted N-terminal amino acid is Met.
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途径
- Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
抗原
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