MIA 蛋白
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- 抗原 See all MIA 蛋白
- MIA (Melanoma Inhibitory Activity (MIA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 序列
- MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ
- 产品特性
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Purified recombinant Human MIA protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4-6 µg/mL. - 纯度
- > 98 % pure
- 内毒素水平
- < 0.1 ng per μg (1 EU/μg).
- Top Product
- Discover our top product MIA 蛋白
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Melanoma Inhibitory Activity (MIA) (Active) protein
MIA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active
Melanoma Inhibitory Activity (MIA) (AA 1-131) protein (GST tag)MIA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Melanoma Inhibitory Activity (MIA) (Transcript Variant 1) (Active) proteinMIA 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
Melanoma Inhibitory Activity (MIA) protein (Myc-DYKDDDDK Tag)MIA 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 说明
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Biological activity: The ED50 was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4-6 μg/mL.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- Lyophilized from 15 mM Na3PO4, pH 7.2 with 75 mM NaCl.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- RT/-20 °C
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- 抗原
- MIA (Melanoma Inhibitory Activity (MIA))
- 别名
- MIA (MIA 产品)
- 背景
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MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family, MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis.
Alternative Names: Cartilage-derived retinoic acid-sensitive protein protein, CD-RAP protein, Melanoma Inhibitory Activity protein - 分子量
- 12.2 kDa
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