GREM1 蛋白
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- 抗原 See all GREM1 蛋白
- GREM1 (Gremlin 1 (GREM1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- CHO Cells
- 序列
- KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
- 产品特性
- Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 μg/mL.
- 纯度
- < 90 % by SDS-PAGE gel and HPLC analyses.
- Top Product
- Discover our top product GREM1 蛋白
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Gremlin 1 (GREM1) (Active) protein
GREM1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） WB, SDS Active
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Gremlin 1 (GREM1) (AA 25-184) protein (His tag)GREM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Gremlin 1 (GREM1) (AA 25-184) protein (His-IF2DI Tag)GREM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Gremlin 1 (GREM1) (AA 75-184) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-124) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (Active) protein (His tag)GREM1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 97 % as determined by SDS-PAGE Active
Gremlin 1 (GREM1) (AA 1-184) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-184) protein (His tag)Crystallography grade GREM1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Gremlin 1 (GREM1) (AA 25-184) protein (His tag)Crystallography grade GREM1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 注意事项
- As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- 储存条件
- -20 °C
- 储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- 有效期
- 24 months
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- 抗原
- GREM1 (Gremlin 1 (GREM1))
- 别名
- Gremlin-1 (GREM1 产品)
- 别名
- grem1 Protein, MGC136702 Protein, zgc:136702 Protein, GREM1 Protein, drm Protein, pig2 Protein, dand2 Protein, ihg-2 Protein, gremlin Protein, Cktsf1b1 Protein, Drm Protein, Grem Protein, ld Protein, gremlin-1 Protein, CKTSF1B1 Protein, DAND2 Protein, DRM Protein, GREMLIN Protein, IHG-2 Protein, cktsf1b1 Protein, gremlin 1a, DAN family BMP antagonist Protein, gremlin 1, DAN family BMP antagonist Protein, gremlin 1 Protein, gremlin 1, DAN family BMP antagonist L homeolog Protein, grem1a Protein, GREM1 Protein, LOC662541 Protein, grem1 Protein, Grem1 Protein, grem1.L Protein
- 背景
- Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.
- 基因ID
- 26585
- NCBI登录号
- NP_001178251
- OMIM
- 300797307
- UniProt
- O60565
- 途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
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