GREM1 蛋白
Quick Overview for GREM1 蛋白 (ABIN2468502)
抗原
See all GREM1 蛋白蛋白类型
生物活性
宿主
资源
纯度
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序列
- KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
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产品特性
- Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 μg/mL.
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Gremlin 1 (GREM1) (Active) protein
GREM1 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） WB, SDS Active
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Gremlin 1 (GREM1) (AA 25-184) protein (His-IF2DI Tag)GREM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Gremlin 1 (GREM1) (AA 25-124) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 1-184) protein (GST tag)GREM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (His tag)GREM1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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限制
- 仅限研究用
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状态
- Lyophilized
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注意事项
- As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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储存条件
- -20 °C
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储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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有效期
- 24 months
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- GREM1 (Gremlin 1 (GREM1))
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别名
- Gremlin-1
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背景
- Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.
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基因ID
- 26585
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NCBI登录号
- NP_001178251
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OMIM
- 300797307
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UniProt
- O60565
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途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
抗原
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