CDNF 蛋白
This Recombinant CDNF protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN2468321
发货至:
中国
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Contact Info
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中国
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北京 101111
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Quick Overview for CDNF 蛋白 (ABIN2468321)
抗原
See all CDNF 蛋白
CDNF
(Cerebral Dopamine Neurotrophic Factor (CDNF))
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
< 98 % by SDS-PAGE gel and HPLC analyses.
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序列
- MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL
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产品特性
- Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/mL.
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内毒素水平
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Cerebral Dopamine Neurotrophic Factor (CDNF) (AA 25-187) protein (His-IF2DI Tag)
CDNF 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Cerebral Dopamine Neurotrophic Factor (CDNF) protein (His tag)CDNF 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
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限制
- 仅限研究用
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状态
- Lyophilized
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注意事项
- As with any protein, exposing CDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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储存条件
- -20 °C
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储存方法
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted CDNF stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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有效期
- 24 months
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- CDNF (Cerebral Dopamine Neurotrophic Factor (CDNF))
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别名
- CDNF
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背景
- CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.
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基因ID
- 441549
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NCBI登录号
- NP_001025125
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OMIM
- 82880674
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UniProt
- Q49AH0
抗原
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