Botulinum C3 Enzyme (Active) 蛋白
This Native Botulinum C3 Enzyme protein is expressed in Clostridium botulinum and has been mentioned in 2+ publications.
1 image
(2 references)
产品编号 ABIN2452165
发货至:
中国
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Quick Overview for Botulinum C3 Enzyme (Active) 蛋白 (ABIN2452165)
抗原
Botulinum C3 Enzyme
蛋白类型
Native
生物活性
Active
宿主
Clostridium botulinum
资源
Clostridium botulinum
应用范围
Functional Studies (Func)
纯度
> 90 % purity by SDS-PAGE (CBB staining)
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应用备注
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1) For the studies on the Rho-dependent signaling pathways in animal cells in vivo and in vitro.
2) ADP-ribosylation of small GTP proteins, such as Rho and Rac proteins.
Activity: Stimulation of human keratinocytes in culture was observed at 50 ng/mL. -
说明
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No toxic effect was observed in two mice injected with 5 ug of C3 enzyme, showing little contamination of lethal neurotoxins from the botulinus culuture in this preparation.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.33 mg/mL
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缓冲液
- 5 mM sodium phosphate buffer ( pH 6.0), 50 % glycerol
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储存条件
- -20 °C/-80 °C
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储存方法
- -20 C (For long term storage: -70 C)
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: "Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation." in: Cell death and differentiation, Vol. 5, Issue 9, pp. 720-8, (1999) (PubMed).
: "Purification and characterization of ADP-ribosyltransferases (exoenzyme C3) of Clostridium botulinum type C and D strains." in: Journal of bacteriology, Vol. 173, Issue 19, pp. 6025-9, (1991) (PubMed).
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: "Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation." in: Cell death and differentiation, Vol. 5, Issue 9, pp. 720-8, (1999) (PubMed).
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- Botulinum C3 Enzyme
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背景
- This product was highly purified from the supernatant of the culture of Clostridium botulinum type C by cation exchange, hydroxyapatite and gel filtration columns. This toxin ADP-ribosylates Rho and Rac, which are low-molecular weight GTP-binding proteins of animal cells, and interrupts the downstream signal transduction pathways. The molecular weight is 24 kDa.
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UniProt
- P15879
抗原
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