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VEGF Protein (AA 27-191)

Name: VEGF Protein (AA 27-191)
SKU: ABIN2181903
Availability: OutOfStock

This Recombinant VEGF protein is expressed in HEK-293 Cells and has been mentioned in 3+ publications.

Human VEGF165 on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. (VEGF Protein (AA 27-191))

SDS

Immobilized Human VEGF165 with a linear range of 3-50 ng/mL. (VEGF Protein (AA 27-191))

Bind

3 images

(3 references)

产品编号 ABIN2181903

发货至: 中国

Quick Overview for VEGF Protein (AA 27-191) (ABIN2181903)

抗原

See all VEGF 蛋白

VEGF (Vascular Endothelial Growth Factor (VEGF))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

HEK-293 Cells

纯度

>98 % as determined by SDS-PAGE.

质量等级

HPLC verified

产品特性

AA 27-191

品牌

ActiveMax®

序列

AA 27-191

产品特性

This protein carries no "tag". The protein has a calculated MW of 19 kDa (monomer). As a result of glycosylation, the protein migrates as 24 kDa (monomer) under reducing (R) condition, and 43-50 kDa (homodimer) under non-reducing (NR) condition (SDS-PAGE).

过滤

0.22 μm filtered

内毒素水平

Less than 1.0 EU per μg by the LAL method.
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Vascular Endothelial Growth Factor (VEGF) (AA 27-191) (Active) protein (Biotin)
VEGF 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (Active) protein
VEGF 宿主: 人宿主: Yeast (Pichia pastoris) > 95 % by SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (AA 27-191) (Active) protein (His tag)
VEGF 宿主: 人宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (AA 27-190) (Active) protein
HPLC verified VEGF 宿主: 小鼠宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (AA 27-147) (Active) protein (AVI tag,His tag,Biotin)
VEGF 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (Active) protein
VEGF 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS-PAGE Func Active

Vascular Endothelial Growth Factor (VEGF) (AA 27-147) (Active) protein (His tag)
VEGF 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (AA 27-146) (Active) protein
VEGF 宿主: 小鼠宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

Vascular Endothelial Growth Factor (VEGF) (AA 27-190) protein (His tag)
VEGF 宿主: Pig 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.

Vascular Endothelial Growth Factor (VEGF) (AA 27-191) protein (His tag)
VEGF 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, Ct

限制

仅限研究用
状态

Lyophilized

缓冲液

PBS, pH 7.4

注意事项

Please avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Stumpf, Wimmer, Lorenz, Stieger: "Creation of different bioluminescence resonance energy transfer based biosensors with high affinity to VEGF." in: PLoS ONE, Vol. 15, Issue 3, pp. e0230344, (2020) (PubMed).

Chen, Hsueh, Lee, Tsai, Tsai, Chiang: "FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK." in: Cellular and molecular life sciences : CMLS, (2020) (PubMed).

Keys, Wetter, Hang, Rutschmann, Russo, Mally, Steffen, Zuppiger, Müller, Schneider, Faridmoayer, Lin, Aebi: "A biosynthetic route for polysialylating proteins in Escherichia coli." in: Metabolic engineering, Vol. 44, pp. 293-301, (2018) (PubMed).
抗原

VEGF (Vascular Endothelial Growth Factor (VEGF))

别名

VEGF

背景

VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.

分子量

19.2 kDa

NCBI登录号

NP_001165097