Neuropilin 1 Protein (NRP1) (AA 22-644) (Fc Tag)
(1 reference)Quick Overview for Neuropilin 1 Protein (NRP1) (AA 22-644) (Fc Tag) (ABIN2181550)
抗原
See all Neuropilin 1 (NRP1) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 22-644
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标记
- This Neuropilin 1 protein is labelled with Fc Tag.
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序列
- AA 22-644
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产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96.5 kDa. The protein migrates as 120-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Neuropilin 1 (NRP1) (AA 22-644) protein (His tag)
NRP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Neuropilin 1 (NRP1) (AA 22-644) protein (His tag)NRP1 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Neuropilin 1 (NRP1) (AA 22-131) protein (GST tag)NRP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neuropilin 1 (NRP1) (AA 23-644) protein (GST tag)NRP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Neuropilin 1 (NRP1) (AA 22-856) protein (His tag)NRP1 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Neuropilin 1 (NRP1) (AA 22-855) protein (His tag)NRP1 宿主: 大鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Neuropilin 1 (NRP1) (AA 22-856) protein (His tag)NRP1 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Neuropilin 1 (NRP1) (AA 22-644) (Active) protein (His tag)NRP1 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Neuropilin 1 (NRP1) (AA 22-644) (Active) protein (mFc Tag)NRP1 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Neuropilin 1 (NRP1) (AA 22-856) (Active) protein (His tag)NRP1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells." in: The Journal of biological chemistry, Vol. 292, Issue 24, pp. 10295-10305, (2017) (PubMed).
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: "Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells." in: The Journal of biological chemistry, Vol. 292, Issue 24, pp. 10295-10305, (2017) (PubMed).
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- Neuropilin 1 (NRP1)
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别名
- Neuropilin-1
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背景
- Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
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分子量
- 96.5 kDa
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途径
- Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
抗原
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