Human Immunodeficiency Virus Surface Glycoprotein (HIV gp120) (AA 34-506) (Active) protein (His tag)
Quick Overview for Human Immunodeficiency Virus Surface Glycoprotein (HIV gp120) (AA 34-506) (Active) protein (His tag) (ABIN2181172)
抗原
蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 34-506
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标记
- His tag
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序列
- AA 34-506
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产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54 kDa. The protein migrates as 65-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Human Immunodeficiency Virus Surface Glycoprotein (HIV gp120) (AA 36-507) (Active) protein (His tag)
HIV gp120 宿主: Human Immunodeficiency Virus (HIV) 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Human Immunodeficiency Virus Surface Glycoprotein (HIV gp120) (AA 36-511) protein (His tag)HIV gp120 宿主: Human Immunodeficiency Virus (HIV) 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Human Immunodeficiency Virus Surface Glycoprotein (HIV gp120) (AA 36-507) (Active) protein (His tag,AVI tag,Biotin)HIV gp120 宿主: Human Immunodeficiency Virus (HIV) 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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- Human Immunodeficiency Virus Surface Glycoprotein (HIV gp120)
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别名
- GP120 (HIV)
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物质类
- Viral Protein
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背景
- Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses. Envelope glycoprotein GP120 (or gp120) is the name of the glycoprotein which forms the spikes sticking out of a HIV virus particle. gp120 is essential for virus entry into cells as it plays a vital role in seeking out specific cell surface receptors for entry. Three gp120s, bound as heterodimers to a transmembrane glycoprotein, gp41, are thought to combine in a trimer to form the envelope spike, which is involved in virus-cell attachment. One half of the molecular weight of gp120 is due to the carbohydrate side chains (the "glyco-" in "glycoprotein"). These are sugar residues which form something almost like a sugar "dome" over the gp120 spikes. This dome prevents gp120 from being recognised by the human immune response. As the HIV virus and the human CD4 cell come together, the gp120 binding site "snaps open" at the last minute.The glycoprotein gp120 is anchored to the viral membrane, or envelope, via non-covalent bonds with the transmembrane glycoprotein, gp41. It is involved in entry into cells by binding to CD4 receptors, particularly helper T-cells. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.
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分子量
- 54.1 kDa
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基因ID
- 17
抗原
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