Long R3 Insulin Like Growth Factor-1 (Active) 蛋白
This Recombinant not_set protein is expressed in 大肠杆菌（E. Coli）.
产品编号 ABIN2018201
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Long R3 Insulin Like Growth Factor-1 (Active) 蛋白 (ABIN2018201)
抗原
Long R3 Insulin Like Growth Factor-1
蛋白类型
Recombinant
生物活性
Active
宿主
人
资源
大肠杆菌（E. Coli）
纯度
> 95 % by SDS-PAGE.
-
-
序列
- MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
-
产品特性
- ED50 < 10 ng/mL, measured by the dose-dependantproliferation of CHO cells, corresponding to a specific activity of >1.0x 10^5 units/mg.
-
内毒素水平
- < 1 EU/μg, determined by LAL method.
-
-
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Reconstituted in 10 mM HCl at 1 mg/mL. Use a 0.22 μm membrane for filter Sterilization.
-
缓冲液
- Lyophilized after dissolved in 48 % acetonitrile and 0.1 % TFA
-
注意事项
- Avoid repeated freeze-thaw cycles.
-
储存条件
- -80 °C
-
储存方法
- Lyophilized recombinant human Long R3Insulin-like Growth Factor-1 (rhLR3IGF-1) remains stable up to 6 months at -80 °C from date of receipt. Stock solution of peptide can be stored at least 3 months at -20 °C.
-
有效期
- 6 months
-
-
- Long R3 Insulin Like Growth Factor-1
-
背景
-
IGF-1 is a well-characterized basic peptide secreted by the liver that circulates in the blood. It has growth-regulating, insulin-like, mitogenic activities. IGF-1 is a growth factor that has a major, but not absolute, dependence on somatotropin. It is believed to be mainly active in adults in contrast to IGF-2, which is also a major fetal growth factor. Human Long R3 Insulin-like Growth Factor-1 (rhLR3IGF-1) contains an 83 amino acid analog of human IGF-I. Compared to the complete human IGF-I sequence, an addition of the rhLR3IGF-1 includes the substitution of an Arg for the Glu at position 3 (hence R3)and a13 amino acid extension peptide at the N-terminus. An enhanced potency is due to the markedly decreased binding of human Long-R3-IGF-I to IGF binding proteins which normally inhibit the biological actions of IGFs. RhLR3IGF-1 is properly folded under oxidizing conditions and then purified by proprietary chromatographic techniques.
Synonyms: Human LR3 Insulin-like Growth Factor-I (LR3-IGF-I) (Receptor Grade) -
分子量
- 9.1±0.9 KDa, observed by reducing SDS-PAGE.
抗原
-
You are here:
