PRSS2 蛋白
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北京 101111
Quick Overview for PRSS2 蛋白 (ABIN1880447)
抗原
See all PRSS2 蛋白蛋白类型
生物活性
宿主
资源
应用范围
纯度
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Protease, serine, 2 (Trypsin 2) (PRSS2) (AA 1-247) protein (GST tag)
PRSS2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Protease, serine, 2 (Trypsin 2) (PRSS2) (Active) protein (His tag)PRSS2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Tris-HCl ( pH 7.4±0.2) with 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Shipat 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
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- PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))
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别名
- Trypsinogen 2
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背景
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Synonyms: Trypsinogen II, TG2
Description: Recombinant full length human TG2 protein with molecular weight 31 kDa.
Background: Trypsinogen is the precursor form or zymogen of the pancreatic enzyme trypsin. It functions as storage of an inactive form of trypsin so that it may be kept in pancreas and released in significant amount when required for protein digestion. Rowen et al. (1996) found thatonly 2 of 3 pancreatically expressed trypsinogen cDNAs correspond to trypsinogen genes in the TCRB locus, T4 was denoted trypsinogen 1 and T8 was denoted trypsinogen 2. The third pancreatic cDNA, identified independently as trypsinogen 3 and 4, is distinct from the third apparently functional trypsinogen gene (T6) in the TCRB locus but related to the other pancreatic trypsinogens. Teich et al. (2004) demonstrated that the E79K mutation in PRSS1 activated anionic trypsinogen 2-fold better than wildtype cationic trypsin did, whereas the common pancreatitis-associated mutants R122H and N29I had no such effect. The observations not only suggested a novel mechanism of action for pancreatitis-associated trypsinogen mutations, but also highlighted the importance of interactions between the 2 major trypsinogen isoforms in the development of genetically determined chronic pancreatitis.
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分子量
- 31 kDa
抗原
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