MA2246 蛋白
Our Local Distributor
北京 101111
Quick Overview for MA2246 蛋白 (ABIN1880440)
抗原
蛋白类型
生物活性
宿主
资源
应用范围
纯度
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Tris-HCl( pH 7.4±0.2) with 0.02 % Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C,-80 °C
-
储存方法
- Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
-
-
- MA2246 (Squamous Cell Carcinoma Antigen (MA2246))
-
别名
- Squamous Cell Carcinoma Antigen
-
背景
-
Description: Recombinant full length human SCCA protein with molecular weight 48 kDa.
Background: Squamous cell carcinoma antigen (SCCA) is a member of the ovalbumin family of serine proteinase inhibitors (serpins). SCCA is detected in the superficial and intermediate layers of normal squamous epithelium, whereas the mRNA is detected in the basal and subbasal levels. A neutral form of the protein (SCCA1, or SERPINB3) is found in normal and some malignant squamous cells, whereas an acidic form (SCCA2, or SERPINB4) is detected exclusively in tumor cells and in the circulation of patients with squamous cell tumors.SCCA1 shares 92 % amino acid identity with SCCA2. Thus, the appearance of the acidic fraction of SCCA is correlated with more aggressive tumors. Ray et al. (2005) proposed that IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma.
-
分子量
- 48 kDa
抗原
-
