Free PSA 蛋白
This Native Free PSA protein is expressed in Human.
Quick Overview for Free PSA 蛋白 (ABIN1880349)
抗原
Free PSA (fPSA)
(Free Prostate Specific Antigen (fPSA))
蛋白类型
Native
宿主
人
资源
Human
纯度
> 90 % by SDS-PAGE
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纯化方法
- Purified
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 M PBS (pH 7.4 +/- 0.2)
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储存液
- Without preservative
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储存条件
- 4 °C
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- Free PSA (fPSA) (Free Prostate Specific Antigen (fPSA))
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别名
- Free PSA
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背景
- Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the members of which are also prostate specific. PSA is a major protein in semen, where its function is to cleave semenogelins in the seminal coagulum. PSA is secreted into prostatic ducts as an inactive 244-amino acid proenzyme (proPSA) that is activated by cleavage of seven N-terminal amino acids. Measurement of free versus total PSA can increase specificity for PCa. PSA is also widely used to monitor responses to therapy and is under investigation as a therapeutic target.
抗原
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